Tetrahedron Letters p. 2529 - 2531 (2001)
Update date:2022-08-03
Topics:
Ikeda, Hisafumi
Yoshida, Kohzo
Ozeki, Makoto
Saito, Isao
We synthesized flavin-containing PNA monomer unit 5 from lumiflavin and prepared PNAs containing a flavin moiety (FPNA) by the standard tBoc chemistry. Each PNA oligomer was purified by reversed-phase HPLC and characterized by MALDI-TOF MS and UV spectra. Thermodynamic analyses indicated that the PNA oligomer containing a flavin moiety near the amino terminal considerably stabilized the PNA-DNA hybrids.
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