The merits of bipartite transition-state mimics for inhibition of uracil DNA glycosylase

DOI: 10.1016/j.bioorg.2004.03.001

Source and publish data:

Bioorganic Chemistry p. 244 - 262 (2004)

Update date:2022-08-02

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Authors:

Jiang, Yu Lin

Cao, Chunyang

Stivers, James T.

Song, Fenhong

Ichikawa, Yoshi

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Article abstract of DOI:10.1016/j.bioorg.2004.03.001

The glycosidic bond hydrolysis reaction of the enzyme uracil DNA glycosylase (UDG) occurs by a two-step mechanism involving complete bond breakage to the uracil anion leaving group in the first step, formation of a discrete glycosyl cation-uracil anion in

Full text of DOI:10.1016/j.bioorg.2004.03.001

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