SYNTHESIS OF NAPAVIN, A NEW PHOTOREACTIVE DERIVATIVE OF VINBLASTINE

DOI: 10.1016/S0040-4039(01)93495-1

Source and publish data:

Tetrahedron Letters p. 5881 - 5882 (1989)

Update date:2022-07-31

Topics:

Authors:

Nasioulas, Georgios

Grammbitter, Klaus

Gerzon, Koert

Ponstingl, Herwig

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Article abstract of DOI:10.1016/S0040-4039(01)93495-1

The synthesis of 3-<<<2-amino(4-azido-2-nitrophenyl)ethyl>amino>carbonyl>-O⁴-deacetyl-3-de(methoxycarbonyl)-vincaleukoblastine (napavin) from vinblastine is described.This new photoreactive cytoststatic substance overcomes multidrug resistance

Full text of DOI:10.1016/S0040-4039(01)93495-1

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