
Journal of Organic Chemistry p. 7334 - 7338 (1992)
Update date:2022-08-05
Topics:
Itoh, Osamu
Honnami, Toshiya
Amano, Akira
Murata, Kouichi
Koichi, Youta
Sugita, Toshio
A Friedel-Crafts-type α-aminoacylation of alkylbenzene with N-carboxy anhydrides of five L-α-amino acids was developed.Five new α-aminoalkyl p-methylphenyl ketones and other α-aminoalkyl aryl ketones were obtained and isolated as free bases or hydrochloride salts.The chiralities of the original L-α-amino acids were retained during this acylation.
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