Friedel-Crafts α-Aminoacylation of Alkylbenzene with a Chiral N-Carboxy-α-amino Acid Anhydride without Loss of Chirality

Article abstract of DOI:10.1021/jo00052a059

A Friedel-Crafts-type α-aminoacylation of alkylbenzene with N-carboxy anhydrides of five L-α-amino acids was developed.Five new α-aminoalkyl p-methylphenyl ketones and other α-aminoalkyl aryl ketones were obtained and isolated as free bases or hydrochloride salts.The chiralities of the original L-α-amino acids were retained during this acylation.