Journal of the Chemical Society. Perkin transactions I p. 690 - 692 (1980)
Update date:2022-08-04
Topics:
Berge, John M.
Roberts, Stanley M.
Suschitzky, Hans
Kemp, John E. G.
The epoxide ring in the β-lactams (2) and (3) was opened regioselectively with aqueous hydroiodic acid; attack by iodide occurred at C-3 preferentially.Thiophenolate ions attacked the epoxy-lactam (2) at C(4) with high selectivity while the epoxide (3) was attacked at C(3) exclusively.The differing selectivities of attack by nucleophiles at the epoxide units are explained in terms of an interplay of steric and electronic impositions owing to the neighbouring β-lactam ring.
View MoreContact:86-21-58226973
Address:No 351,Guoshoujing Road, Zhangjiang Hi-tech Park, Pudong, Shanghai, China
website:http://www.np-chem.com
Contact:0086-25-52346877
Address:199, Jian Ye Road, Nanjing, China
Nanjing Chemzam Pharmtech Co., Ltd.
Contact:+86-25-86462165,+86-13915979898
Address:C5-1，6 Maiyue Road，Maigaoqiao，Nanjing，Jiangsu，China
Shanghai Kefu Chemical Co.,Ltd.
Contact:+86-21-34616196
Address:Room601-602, Xuhui Business Building, No.168, Yude Road, Shanghai
Shanghai ZaiQi Bio-Tech Co., Ltd.,
Contact:+86-21-5482 4098
Address:Bldg. No.7, No.201 MinYi Rd，Songjiang CaoHeJing High-Tech Park Shanghai 201516 P,R,China
Doi:10.1007/BF01435827
(1996)Doi:10.1246/bcsj.53.1769
(1980)Doi:10.1021/ja01543a036
(1958)Doi:10.1021/jo01313a017
(1980)Doi:10.1016/S0022-328X(00)90641-7
(1980)Doi:10.1016/0040-4039(80)80107-9
(1980)
