STEREOSELECTIVE REDUCTION OF C-2 SUBSTITUTED STEROID C-3 KETONES WITH LITHIUM TRIS-(R,S-1,2-DIMETHYLPROPYL)-BOROHYDRIDE AND SODIUM BOROHYDRIDE

Article abstract of DOI:10.1016/0039-128X(86)90020-6

The effect of C-2 substitution on the stereoselective reduction of steroid C-3 ketones with lithium tris(R,S-1,2-dimethylpropyl)-borohydride and sodium borohydride was investigated.The C-2 mono- and di-substituted chloro and methyl derivatives were predominantly reduced to one of the epimeric alcohols.The 2α-chloro and 2α-methyl derivatives of 17β-acetoxy-5α-androstan-3-one undergo stereoselective reduction with lithium tris (R,S-1,2-dimethylpropyl)-borohydride to the axial (3α) alcohol as observed in the unsubstituted compound, whereas sodium borohydride gives predominantly the equatorial (3β) alcohol.The 2β-chloro, 2β-methyl, 2,2-dichloro, and 2,2-dimethyl derivatives are reduced predominantly to the equatorial (3β) alcohol by both reagents.