Journal of Medicinal Chemistry p. 1826 - 1830 (1995)
Update date:2022-08-04
Topics:
Kumar, Virendra
Carbateas, Phil M.
Dority, John A.
Earley, William G.
Mallamo, John P.
et al.
Replacement of the pyridinium ring of 6,11-ethanobenzoquinolizinium cations with thiazolium (4a and 4b) and N-methylimidazolium (4c and 4d) resulted in equipotent compounds in the <3H>TCP binding assay.The corresponding N-methyl-1,2,4-triazolium analogs were less potent in this assay.The thiazolium derivative 4b, with a Ki = 2.9 nM, is being evaluated as a possible neuroprotective N-methyl-D-aspartic acid (NMDA) anatgonist.
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