Antihypertensive 5,6-diarylpyridazin-3-ones

DOI: 10.1021/jm00186a021

Source and publish data:

Journal of Medicinal Chemistry p. 1398 - 1405 (1980)

Update date:2022-08-05

Topics:

Authors:

Buchman Buchman

Scozzie Scozzie

Ariyan Ariyan

Heilman Heilman

Rippin Rippin

Pyne Pyne

Powers Powers

Matthews

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Article abstract of DOI:10.1021/jm00186a021

The synthesis of a series of 5,6-diarylpyridazinones is described. Some members of this series display an antihypertensive effect in both the spontaneously hypertensive rat model and the deoxycorticosteroid (DOCA) model of hypertension. The most potent co

Full text of DOI:10.1021/jm00186a021

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