Journal of Medicinal Chemistry p. 218 - 221 (1981)
Update date:2022-08-05
Topics: Structure-Activity Studies Narcotic Antagonists N-Substituted
Jacoby, Ronald L.
Boon, Dick
Darling, Leonard E.
Willette, Robert E.
A number of N-substituted ethyl 3-(m- or p-hydroxyphenyl)nipecotates were synthesized to evaluate the role of a m- or p-hydroxy substituted β-phenethylamine moiety in narcotic antagonist action.Ethyl m- or p-methoxyphenylcyanoacetate was alkylated with 1-
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