Structure-Activity Studies on Narcotic Antagonists. 2. N-Substituted Ethyl 3-(m- or p-Hydroxyphenyl)nipecotates

DOI: 10.1021/jm00134a020

Source and publish data:

Journal of Medicinal Chemistry p. 218 - 221 (1981)

Update date:2022-08-05

Topics: Structure-Activity Studies Narcotic Antagonists N-Substituted

Authors:

Jacoby, Ronald L.

Boon, Dick

Darling, Leonard E.

Willette, Robert E.

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Article abstract of DOI:10.1021/jm00134a020

A number of N-substituted ethyl 3-(m- or p-hydroxyphenyl)nipecotates were synthesized to evaluate the role of a m- or p-hydroxy substituted β-phenethylamine moiety in narcotic antagonist action.Ethyl m- or p-methoxyphenylcyanoacetate was alkylated with 1-

Full text of DOI:10.1021/jm00134a020

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