Structure-Activity Studies on Narcotic Antagonists. 2. N-Substituted Ethyl 3-(m- or p-Hydroxyphenyl)nipecotates

DOI: 10.1021/jm00134a020

Source and publish data:

Journal of Medicinal Chemistry p. 218 - 221 (1981)

Update date:2022-08-05

Topics: Structure-Activity Studies Narcotic Antagonists N-Substituted

Authors:

Jacoby, Ronald L.

Boon, Dick

Darling, Leonard E.

Willette, Robert E.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00134a020

A number of N-substituted ethyl 3-(m- or p-hydroxyphenyl)nipecotates were synthesized to evaluate the role of a m- or p-hydroxy substituted β-phenethylamine moiety in narcotic antagonist action.Ethyl m- or p-methoxyphenylcyanoacetate was alkylated with 1-

Full text of DOI:10.1021/jm00134a020

Products guided by the article

Product name:ethyl 5-chloro-2-cyano-2-(p-methoxyphenyl)valerate

Cas No:75910-83-7

R&D Labs maybe for 75910-83-7

Shandong Loyal Chemical industrial Co.,Ltd

Contact:0533-7451788

Address:Linzi Chemical Industrial Park, Zibo, Shandong Province
Dongying J&M Chemical Co., Ltd,

Contact:546-8551108

Address:Room 1219, Zisheng Mansion, Zibo Road, Dongying, Shandong, China
SHANDONG CREDAGRI CHEMICAL CO., LTD.

Contact:+86-531-88872050

Address:ROOM 601A, BUILDING 2, SHUNTAI SQUARE, NO. 2000 SHUNHUA ROAD, HI-TECH DEVELOPMENT ZONE, JINAN, CHINA.
Wuhan Kemi-Works Chemical Co., Ltd

website:http://www.kemiworks.com

Contact:86-27-85736489

Address:Rm. 1503, No. 164, Jianghan North Rd., Wuhan, 430022 China
Sino-Japan Chemical Co., Ltd.

website:http://www.sjc.com.tw

Contact:(886) 2-2396-6223

Address:14Fl., No. 99. Sec. 2, Jen Ai Road

Relevant to this article

Doi:10.1039/c39750000612
(1975)
Dendritic metalloporphyrins with a distal H-bond donor as mimics of haemoglobin.

Doi:10.1039/b212468h
(2003)
Chromophore Relaxation in a Side-Chain Methacrylate Copolymer Functionalized with 4-[N-Ethyl-N-(2-hydroxyethyl)]ammo-2′-chloro-4′- nitroazobenzene

Doi:10.1021/ma035714j
(2004)
Metal-Free Reduction of Aromatic and Aliphatic Nitro Compounds to Amines: A HSiCl₃-Mediated Reaction of Wide General Applicability

Doi:10.1021/acs.orglett.5b01698
(2015)
Doi:10.1002/jps.2600670903
(1978)
Efficient and atom-economic synthesis of α-substituted β-chromonyl-α,β-unsaturated carbonyls through molecular rearrangement

Doi:10.1055/s-0029-1219176
(2010)

Article Doi