2-Oxo-1,8-naphthyridine-3-carboxylic Acid Derivatives with Potent Gastric Antisecretory Properties

DOI: 10.1021/jm00395a015

Source and publish data:

Journal of Medicinal Chemistry p. 2270 - 2277 (1987)

Update date:2022-09-26

Topics:

Authors:

Santilli, Arthur A.

Scotese, Anthony C.

Bauer, Raymond F.

Bell, Stanley C.

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Article abstract of DOI:10.1021/jm00395a015

The syntheses of 2-oxo-1,8-naphthyridine-3-carboxylic acid derivatives having potent gastric antisecretory properties in the pyloric-ligated (Shay) rat model are described.Two of the more potent compounds tested that were selected for more detailed dose-r

Full text of DOI:10.1021/jm00395a015

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