Journal of Organometallic Chemistry p. 139 - 147 (1981)
Update date:2022-08-03
Topics:
Marsais, Francis
Breant, Patrice
Ginguene, Alain
Queguiner, Guy
Lithium dialkylamides metalate 3-chloropyridine with excellent regioselectivity at position 4.This reaction occurs in THF solution at -60 deg C and it leads to various 3,4-disubstituted pyridines in good yields.This regioselectivity is completely changed in ether solution by using the butyllithium-TMEDA complex.In that case position 2 is metallated and 2,3-disubstituted pyridines are obtained.
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(2004)Doi:10.1021/om0343824
(2004)Doi:10.1021/jm00197a011
(1979)Doi:10.1016/j.tetlet.2005.03.027
(2005)Doi:10.1016/0040-4039(81)80075-5
(1981)
