Regioselective ortho lithiation of halopyridines

DOI: 10.1016/S0040-4039(00)93671-2

Source and publish data:

Tetrahedron Letters p. 4137 - 4140 (1980)

Update date:2022-08-04

Topics:

Authors:

Gribble, Gordon W.

Saulnier, Mark G.

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Article abstract of DOI:10.1016/S0040-4039(00)93671-2

Regioselective ortho lithiation of 2-, 3-, and 4-halopyridines is achieved with lithium diisopropylamide (-78°, tetrahydrofuran) to afford, upon quenching with electrophilic reagents, 2,3- and 3,4-disubstituted pyridines in good to excellent yield.

Full text of DOI:10.1016/S0040-4039(00)93671-2

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