Tetrahedron Letters p. 4137 - 4140 (1980)
Update date:2022-08-04
Topics:
Gribble, Gordon W.
Saulnier, Mark G.
Regioselective ortho lithiation of 2-, 3-, and 4-halopyridines is achieved with lithium diisopropylamide (-78°, tetrahydrofuran) to afford, upon quenching with electrophilic reagents, 2,3- and 3,4-disubstituted pyridines in good to excellent yield.
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(1968)
