Journal of the Chemical Society. Perkin transactions I p. 599 - 606 (1981)
Update date:2022-07-31
Topics:
Gill, Melvyn
Rickards, Rodney W.
Terminally functionalised 3-alkyl-4-hydroxycyclopent-2-enones are prepared by conjugate addition-elimination reactions of magnesiocuprate reagents with ethers of 3-chloro-4-hydroxycyclopent-2-enone.The side-chain functionality can be modified either selectivity, or simultaneously with modification of the nucleus.Stereospecific trasposition of the ring-oxygen functions converts these compounds into terminally functionalised 2-alkyl-4-hydroxycyclopent-2-enones which are important intermediates in prostanoid synthesis.Thus the 2-substituted cyclopentenone (2) is prepared in ca. 60percent yield from the 3-chlorocyclopentenone (7), itself available in four steps from phenol.
View MoreLaohekou Jinghong Chemical Co.,Ltd
Contact:+86-0710-3702747
Address:163.East，Huagong Road，Laohekou
Contact:
Address:
Contact:+86-21-54391580
Address:Room 502,No.65,Lane 2388 Hongxin Road,Shanghai,China
Beijing Century Richap Chemistry Co.,Ltd
Contact:+86- 010-64455497
Address:Guannan County, Lianyungang City, Jiangsu Province, China
Ceresking Ecology & Technology co.,ltd
Contact:86 22 66218397
Address:Room 1613, Zheshang Mansion, No. 1988, Yingbin Avenue, Binhai New District, Tianjin,China.
Doi:10.1021/ja00397a059
(1981)Doi:10.1021/acs.jmedchem.6b01718
(2017)Doi:10.1021/acs.orglett.0c01914
(2020)Doi:10.1021/acs.joc.5b00771
(2015)Doi:10.1016/0040-4039(81)80045-7
(1981)Doi:10.1246/bcsj.59.221
(1986)
