A HIGHLY SELECTIVE N-PROTECTION STRATEGY FOR THE PREPARATION OF 1-N-ALKYLATED KANAMYCIN ANTIBIOTICS

DOI: 10.1016/S0040-4039(00)71171-3

Source and publish data:

Tetrahedron Letters p. 4981 - 4984 (1980)

Update date:2022-08-05

Topics:

Authors:

Thomas, Michael B.

Williams, Michael T.

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Article abstract of DOI:10.1016/S0040-4039(00)71171-3

An O to N acyl migration technique has been used to selectively acetylate the amino groups of the aminosugar rings of kanamycins A and B, leaving the amino groups on the 2-deoxy-streptamine ring unprotected.A formylation-deformylation process then convert

Full text of DOI:10.1016/S0040-4039(00)71171-3

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