Synthesis of analogues of acetylmethadol and methadol as potential narcotic antagonists

DOI: 10.1021/jm00139a030

Source and publish data:

Journal of Medicinal Chemistry p. 903 - 906 (1981)

Update date:2022-07-30

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Authors:

Lattin Lattin

Caviness

Hudson Hudson

Greene Greene

Raible Raible

Richardson

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Article abstract of DOI:10.1021/jm00139a030

The N-allyl and N-(cyclopropylmethyl) analogues of (-)-α-acetylmethadol and (-)-α-methadol have been synthesized and evaluated for opiate agonist and opiate antagonist activity. Both acetylmethadol analogues possessed weak analgesic activity in in vivo te

Full text of DOI:10.1021/jm00139a030

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