ASYMMETRIC TRANSFORMATION OF AMINO ACIDS IN N-SALICYLIDENE AMINO ACYL-L-ISOLEUCINATOCOPPER(II)

Article abstract of DOI:10.1246/cl.1980.1271

A new asymmetric transformation of amino acids was described.Thus, when N-salicylidene-D-alanyl-, D-phenylalanyl-, or D-phenyl-glycyl-L-isoleucinatocopper(II) was incubated at pH 8.5 and 80 deg C, the resulting mixture at equilibrium contained a complex of L-L-dipeptide in the contents of 63-76percent.The epimerization of dipeptides is based on the enhanced activity of N-terminal amino acids through complex formation.