A STUDY OF THE PRODUCTS OF THE REDUCTION OF THE ANTIBIOTIC REUMYCIN (6-METHYLPYRIMIDOTRIAZINE-5,7-DIONE)

Article abstract of DOI:10.1007/BF00566439

The structures of the products of the reduction of the antibiotic reumycin (I), which is a specific autooxidizable acceptor of reducing equivalents from certain flavin dehydrogenases of the respiratory chain of the mitochondria of yeast and animal tissues, have been established with the aid of physicochemical methods (UV, IR, and PMR spectroscopy and mass spectrometry).In the determination of the structures of five reduction products of reumycin effective use has been made of high-resolution mass spectrometry and a consideration of the spectra of metastable ions (the DADI technique).It has been shown that only the asym-triazine ring in the initial (I) undergoes reduction and ring opening.