New Dimeric Indole Alkaloids from Stenosolen heterophyllus: Structure Determinations and Synthetic Approach

Article abstract of DOI:10.1021/jo00344a011

Structures of eight new dimeric indole alkaloids of the ervafoline 1-4 and ervafolidine series 5-8, isolated from Stenosolen heterophyllus (Vahl) Mgf (Apocynaceae), were investigated by use of mass spectrometry, 1H and 13C nuclear magnetic resonance, and X-ray crystallography.A biogenetic pathway was proposed to take into account the formation of these unusual alkaloids, and, finally, a synthetic approach based on this proposal has been developed.