European Journal of Medicinal Chemistry p. 1745 - 1750 (2009)
Update date:2022-09-26
Topics:
Duesman Tonin, Lilian T.
Barbosa, Valeria A.
Bocca, Cleverson Cassero
Ramos, Erika R.F.
Nakamura, Celso V.
Ferreira da Costa, Willian
Basso, Ernani A.
Nakamura, Tania U.
Sarragiotto, Maria Helena
The cis and trans isomers of methyl 1-(m-nitro)phenyl and 1-(p-nitro)phenyl-1,2,3,4-tetrahydro-9H-β-carboline-3-carboxylates (compounds 3a,b, 4a and b) were synthesized and evaluated in vitro against epimastigote forms of Trypanosoma cruzi. Among all of the evaluated tetrahydro-β-carboline derivatives, the compound trans-methyl 1-(m-nitro)phenyl-1,2,3,4-9H-tetrahydro-β-carboline-3-carboxylate (3b) was found to exhibit significant trypanocidal activity (IC50 = 22.2 μM). Theoretical studies of molecular conformations and electronic properties for the synthesized compounds and benznidazole, as well as, the cyclic voltammetric (CV) behaviors' determination were performed. A comparative study of the trypanocidal activity of the nitrophenyl-tetrahydro-β-carbolines derivatives and benznidazole, using the results of theoretical calculations and of the cyclic voltammetry experiments, is presented.
View Moreshandong lukang animal & plant drug trading co.,ltd.
Contact:15853765968
Address:floor 9, lukang ,jingying building,#173,taibai building west road,jining city,shandong,china
Contact:86-571-61063068
Address:LINAN
Zibo Kunran Enterprises Co. LTD
website:http://www.kunranchem.com
Contact:0086 533 5200669
Address:No. 96 Jinjing Avenue, Zibo, Shandong, China
website:http://www.sjc.com.tw
Contact:(886) 2-2396-6223
Address:14Fl., No. 99. Sec. 2, Jen Ai Road
website:http://www.greenutra.cn
Contact:0086-411-39553357
Address:No. 7-1-1802, Huizhi Garden,Ocean Square,Dalian, 116033, China
Doi:10.1016/S0022-328X(00)84333-8
(1982)Doi:10.1055/s-2004-829172
(2004)Doi:10.1021/jm00143a018
(1981)Doi:10.1016/S0040-4020(01)00042-4
(2001)Doi:10.1080/00397911.2019.1590848
(2019)Doi:10.1021/jo01014a006
(1965)