General Strategies for Alkaloid Synthesis via Intramolecular Cycloadditions of Enamides. Application to the Formal Total Synthesis of Racemic Lycorine.

Article abstract of DOI:10.1021/jo00331a049

The application of the intramolecular <4 + 2> cycloaddition of the enamido diene 6 to the construction of the unsaturated oxolycorane 2 is described, thereby completing a novel, formal synthesis of the Amaryllidaceae alkaloid lycorine (1).