Synthesis and Evaluation of 1,2,3,4-Tetrahydrobenzothienoisoquinolines as Dopamine Antagonists

Article abstract of DOI:10.1021/jm00141a021

1,2,3,4-Tetrahydro<1>benzothieno<2,3-h>isoquinolines were prepared and evaluated as dopamine antagonists and for potential neuroleptic activity.These compounds, which are analogues of the dopamine agonist apomorphine (2) in which the C-7 methylene has bee