Monatshefte fur Chemie p. 517 - 528 (1981)
Update date:2022-08-04
Topics:
Buchbauer, Gerhard
Pernold, Waltraud
Rassl, Dorothea
Blach, Brigitte
The synthesis of some new potentially, nitrogenefree spasmolytics is described.Formally the benzene nucleus in some mandelic acid esters, known by their spasmolytic activity, is substituted for the isocamphane bicyclus by a) SeO2 oxidation of 1-(3,3-Dimethyl-2-exo-norbornyl)-ethanone (5) to the corresponding ketoaldehyde 6, b) oxidation of 6 to the isocamphane analogous mandelic acid 4 and c) esterification of derivatives of 4 with isoamylalcohol and benzylalcohol.Attemps to dehydrate the methylester 7 to camphenylideneacetic acid methylester (12) by various methods failed, probably because of the ring strain. - Keywords: Camphenylideneacetic acid; Dehydration; Dehydrohalogenation; Esterification; α-Hydroxy acid, with norbornane skeleton; Riley oxidation; Spasmolytics
View MoreHubei Sibo Technology Co.,Ltd.
Contact:0715-6597222
Address:Pan Jia Wan fan Lake Chemical Industrial Park ,Xianning City, Hubei, China
Shanghai Longjin Metallic Material Co., Ltd.
website:http://www.shlongjin.cn/
Contact:021-56517503,56502257
Address:No.16, Lane 555, Chengyin Road, Shanghai
Nantong Baokai Chemical Co., Ltd (Hangzhou Baokai Bio-Chemicals Co.,Ltd.)
Contact:+86-513-83886111
Address:No. 68 Suzhou road ,Binjiang Fine Chemical Industrial Park , Beixin town, Qidong city ,Jiangsu province
Xiamen Hisunny Chemical Co.,Ltd
website:http://www.hisunnychem.com
Contact:+86-592-3327115
Address:Unit 603,No.879,Xiahe Road,Meixin Building,Xiamen,China
Yuan Shi(SuQian)Biotechnology Co.,Ltd
website:http://www.yuanshibio.com
Contact:+86-527-84226672
Address:jiangsu suqian
Doi:10.1016/j.tetlet.2014.09.034
(2014)Doi:10.1016/j.tetlet.2004.08.073
(2004)Doi:10.1021/ja01102a042
(1953)Doi:10.1021/jo00337a040
(1981)Doi:10.1002/hlca.202000190
(2020)Doi:10.1021/ol040043a
(2004)