Bulletin of the Chemical Society of Japan p. 2853 - 2854 (1983)
Update date:2022-08-05
Topics:
Obase, Hiroyuki
Nakamizo, Nobuhiro
Takai, Haruki
Teranishi, Masayuki
3-<1-(2-Aryl-2-hydroxyethyl)-4-piperidylene>-1,3-dihydro-2H-indol-2-one with structure II, as potential antihypertensive agent was synthesized.The intermediates, 3-<1-(2-aryl-2-oxoethyl)-4-piperidylidene>-1,3-dihydro-2H-indol-2-one (5) were prepared from 4-piperidone via 4 steps.Selective reduction of carbonyl group in 5 was realized using diisobutyl aluminium hydride to afford compound II.
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Doi:10.1016/S0040-4020(01)98930-6
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