Journal of the Chemical Society. Chemical communications p. 151 - 153 (1974)
Update date:2022-08-03
Topics:
Peel
Sutherland
This is a detailed description of 1 route to the chemical synthesis of PGs (prostaglandins) and their analogs in the laboratory. The chemical formula and chemical structure of each step in the chain is diagrammed. The aldehyde had served as intermediary in the synthesizing process in previous experiments. In this series of steps, the starting stage was the Prins reaction of norbornadiene and paraform-aldehyde in formic acid. Lactones were used as starting materials in the synthesis. Hydrolysis and oxidation were used to change 1 substance in the process into the next.
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