Bulletin of the Chemical Society of Japan p. 2136 - 2141 (1981)
Update date:2022-08-02
Topics: Chiral Catalyzed Asymmetric Hydrogenation Preparation Application Cobalt(II) Achiral Cocatalyst Benzil
Takeuchi, Seiji
Ohgo,Yoshiaki
As a new type of chiral cocatalyst in the achiral base-coordinated bis(dimethylglyoximato)cobalt(II)-chiral cocatalyst system, tertiary amines with an amide group at α- or β-carbon were prepared, and asymmetric hydrogenation was examined by using them.The optical yield reached 34.5percent enantiomeric excess(ee) by using N-<(2S,3S)-2-acetoxy-3-dimethylamino-3-phenylpropionyl>-(R)-α-methylbenzylamine; this is the highest value attained so far in the asymmetric hydrogenation of methyl N-(acetylamino)acrylate with this system.The enantioselectivity in the hydrogenation of methyl N-(acetylamino)acrylate was reversed with a configurational alteration of the α-methylbenzylamine moiety of N-
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Doi:10.1002/jhet.1578
(2013)Doi:10.1055/s-2004-831301
(2004)Doi:10.1246/cl.2004.1322
(2004)Doi:10.1016/S0022-328X(00)81005-0
(1981)Doi:10.1139/v83-058
(1983)Doi:10.1016/S0008-6215(00)87140-2
(1981)