Synthesis and Neuroleptic Activity of N--2-methoxy-5-sulfonamidobenzamides

DOI: 10.1021/jm00375a009

Source and publish data:

Journal of Medicinal Chemistry p. 1137 - 1141 (1984)

Update date:2022-08-02

Topics:

Authors:

Ogata, Masaru

Matsumoto, Hiroshi

Kida, Shiro

Shiomi, Teruo

Eigyo, Masami

Hirose, Katsumi

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00375a009

A series of some novel N-<(1-ethyl-2-pyrrolidinyl)methyl>benzamides involving replacement of the sulfamoyl group in sulpiride with a sulfonamido group was synthesized and tested for dopamine receptor blockade.In comparison with sulpiride, several compounds were considerably more potent than sulpiride as dopamine receptor blockers.The structure-activity relationships are discussed.

Full text of DOI:10.1021/jm00375a009

Products guided by the article

Product name:2-Methoxy-5-<(N-methyl-N-methanesulfonyl)amino>benzoyl chloride

Cas No:80494-93-5

R&D Labs maybe for 80494-93-5

xujianqiang

Contact:86-21-57725962

Address:shanghai
Shanghai Bocimed Pharmaceutical Co., Ltd.

website:http://www.bocimed.com

Contact:+86-21-68861632

Address:Building 1, Lane 647, Songtao Road, Zhangjiang High-Tech Park, Shanghai
Shandong Zhongcheng Barium Salt Co., Ltd

Contact:+86-15725732638

Address:No.29 baoxi road, hi-tech zone, zibo, shandong
Tianjin Chemsyntech Chemical Co., Ltd

Contact:+86-22-60872258

Address:Haitai green industry base in Tianjin, K1,5-601
PharmaResources(Kaiyuan)CO,.Ltd

Contact:+86-21-50720028

Address:No.3, Beihuan Road, Economic Development District, Kaiyuan City, Tieling City, Liaoning Province, China 112300

Relevant to this article

(Carbomethoxy)maleic Anhydride, a Highly Reactive New Dienophile and Comonomer

Doi:10.1021/jo00347a014
(1982)
Lewis acid catalysis in heterolysis reactions of glycol ether radicals mimicking diol dehydratase-catalyzed reactions

Doi:10.1021/ol0481131
(2004)
Monomers for oligonucleotide synthesis with linkers carrying reactive residues: I. The synthesis of deoxynucleoside derivatives with methoxyoxalamide groups in heterocyclic bases

Doi:10.1023/B:RUBI.0000030129.13466.18
(2004)
A facile synthesis of dihydrobenzofuranols by photocyclization of (2-alkoxy-5-methyl-phenyl)(aryl) methanone and Ethyl 2-aroyl-4- methylphenyloxyacetates

Doi:10.1002/hc.20111
(2005)
Doi:10.1021/ja01122a023
(1952)
Total synthesis of the natural carbazoles Murrayanine and Murrayafoline A, based on the regioselective Diels-Alder addition of exo-2-oxazolidinone dienes

Doi:10.1055/s-2004-831213
(2004)

Article Doi