Synthesis and Neuroleptic Activity of N--2-methoxy-5-sulfonamidobenzamides

DOI: 10.1021/jm00375a009

Source and publish data:

Journal of Medicinal Chemistry p. 1137 - 1141 (1984)

Update date:2022-08-02

Topics:

Authors:

Ogata, Masaru

Matsumoto, Hiroshi

Kida, Shiro

Shiomi, Teruo

Eigyo, Masami

Hirose, Katsumi

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Article abstract of DOI:10.1021/jm00375a009

A series of some novel N-<(1-ethyl-2-pyrrolidinyl)methyl>benzamides involving replacement of the sulfamoyl group in sulpiride with a sulfonamido group was synthesized and tested for dopamine receptor blockade.In comparison with sulpiride, several compounds were considerably more potent than sulpiride as dopamine receptor blockers.The structure-activity relationships are discussed.

Full text of DOI:10.1021/jm00375a009

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