1,2-dithia-5-azacyclooctan-6-one and related compounds: Synthesis and conformation

Article abstract of DOI:10.1016/S0040-4020(97)10087-4

The first synthesis of 1,2-dithia-5-azacyclooctan-6-one 11, the parent member of a heterocyclic ring synthesis is reported. Compound 11 was found by hoe experiments to exist in a conformation with a trans-amide bond. The substituted derivatives 12 and 13 were also prepared and compound 12 was found to possess a trans-amide bond whilst for compound 13 three conformations were identified with the major conformer possessing a cis- amide bond.