Journal of Pharmaceutical Sciences p. 410 - 412 (1986)
Update date:2022-08-02
Topics:
Mehta
Musso
The synthesis of a hapten useful in the radioimmunoassay of bupropion is described. Since bupropion has no functional group that can be easily derivatized, a hydroxypropyl group was incorporated into the molecule. Studies in cross-reactivity with possible metabolites required the synthesis of the 4'-hydroxy analogue of bupropion. This synthesis is also described.
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