Bioorganic and Medicinal Chemistry Letters p. 5895 - 5898 (2004)
Update date:2022-08-02
Topics:
Park, Eun-Jung
Min, Hye-Young
Ahn, Yong-Hyun
Bae, Cheol-Man
Pyee, Jae-Ho
Lee, Sang Kook
The inhibitory effects of pinosylvin analogues on the production of COX-2 mediated PGE2 were evaluated in a cell culture system. A new series of potential inhibitors, including 3-hydroxy-5-benzyloxy-trans-stilbene and 3,5-dimethoxy-trans-stilbene, have been identified. A series of natural stilbenoids, pinosylvin and its derivatives, were synthesized and evaluated for the inhibitory activity of prostaglandin E2 production in lipopolysaccharide-induced RAW 264.7 cells. Potential inhibitors, including 3,5-dimethoxy-trans-stilbene and 3-hydroxy-5-benzyloxy-trans-stilbene, have been newly identified, and thus providing chemical leads for the further development of anti-inflammatory or cancer chemopreventive agents.
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