Chemistry Letters p. 365 - 368 (1982)
Update date:2022-08-03
Topics:
Yoneda, Fumio
Koga, Ryosuke
Higuchi, Masatsugu
Treatment of phenylazomalonamidamidine (I) with aryl aldehydes yielded the corresponding 2,8-diarylhypoxanthines (II) in single step.The reaction under milder conditions formed the intermediary monoarylidene derivatives (III) of I, from which the corresponding 6-amino-2-aryl-5-phenylazopyrimidine-4(3H)-ones (IV) were obtained by the oxidative cyclization with diethyl azodicarboxylate.Treatment of IV with second aryl aldehydes gave the unsymmetrical 2,8-diarylated hypoxanthines.
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