Improved Synthesis of chlamydocin: Cyclization Studies of Tetrapeptides Containing Five α-Substituents

Article abstract of DOI:10.1021/jo00136a033

A complete search for the optimal conditions for preparing cycling tetrapeptide 2 was carried out.In this study all four possible sequences of the linear tetrapeptide precursors were synthesized and cyclized.The results establish that one linear sequence is especially favorable for synthesizing the peptide ring system in chlamydocin (1).