PREPARATION OF HOMOLOGS OF L-2-AMINO-5-(p-METOXYPHENYL)PENTANOIC ACID

Article abstract of DOI:10.1246/bcsj.55.918

Lower and higher homologs, L-2-amino-4-(p-methoxyphenyl)butanoic acid (L-amb) and L-2-amino-6-(p-methoxyphenyl)hexanoic acid (L-Amh), of L-2-amino-5-(p-methoxyphenyl)pentanoic acid were prepared by optical resolution of N-acetyl-DL-Amb and of N-acetyl-DL-Amh with Aspergillus acylase.N-acetyl DL-Amb or N-acetyl-DL-Amh was synthesized from <2-(p-methoxyphenyl)ethyl or butyl>(acetamido malonic acid by heating with p-xylene.