PALLADIUM-PROMOTED ASYMMETRIC OXYAMINATION OF ALKENES APPLICATION TO THE SYNTHESIS OF OPTICALLY ACTIVE ARYLOXYPROPANOLAMINES

Article abstract of DOI:10.1016/S0040-4039(00)86989-0

Palladium-promoted oxyamination of some alkenes using optically active N-methyl-α-phenylethylamine as amine nucleophile, or using optically active N,N-dimethyl-α-phenylethylamine as ligand, produces optically active aminoalcoholderivatives in an optical yield of 3-60percent.Oxyamination of aryl allyl ethers gives optically active 1-amino-3-aryloxy-propan-2-ol derivatives, which are important β-blockers.