Journal of the Chemical Society. Perkin transactions I p. 1623 - 1626 (1985)
Update date:2022-08-05
Topics:
Brown, Michael D.
Gillon, David W.
Meakins, G. Denis
Whitham, Gordon H.
Although α-mercapto ketones react with cyanamides to give substituted 2-aminothiazoles the yields are satisfactory in only the simplest cases.However, a range of 2-aminothiazoles with substituents on the ring or the exo-nitrogen atom was obtained efficiently by the following one-pot procedure: a solution of an α-mercapto ketone anion was generated by treating an O-ethyl S-2-oxoethyl dithiocarbonate with piperidine at 20 deg C, a cyanamide was added, and the solution was heated for 3-6 h.
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