Journal of Pharmaceutical Sciences p. 619 - 621 (1986)
Update date:2022-09-26
Topics:
Holshouser
Kolb
High yields of potential glycol metabolites of p-synephrine, epinephrine, octopamine, and normacromerine can be obtained from the readily available monosubstituted and disubstituted acetophenones. The general procedure involves alpha-bromination followed by displacement with acetate ion and reduction with lithium aluminum hydride. Yields ranged from 46 to 91%. Furthermore, the procedure minimizes some problems inherent in aromatic glycol synthesis which include dimerization and pinacol-pinacolone rearrangement.
View MoreHe Bei Shun Er Chemical Co., LTD.
Contact:86-0311-86996932/86860168
Address:No 18,North street
QINGDAO TAOSIGN INTERNATIONAL TRADE CO.,LIMITED
Contact:+86-0532-82683616
Address:RM1402, Doublestar Seacoase 7#, No. 5 Guizhou Road, Qingdao, Shandong, China
PINGYUAN SIHUAN PHARMACEUTICAL CO., LTD
Contact:+86-531-55696072
Address:#2766,yinxiu Road, Economic Development Zone, Pingyuan Country, Shandong Province, China.
Xinchang Yueding Chemical Co., Ltd.
Contact:86-571-56926323
Address:NO.90 BEIMENCHENGWAI CHENGGUAN TOWN XINCHANG
Xinjiang Zhongtai Chemical Co., Ltd.
Contact:+86-991-8788172
Address:NO.78 XISHAN RD.URUMQI,CHINA
Doi:10.1002/ejoc.201200063
(2012)Doi:10.1002/chem.201404877
(2015)Doi:10.1021/jo01289a049
(1980)Doi:10.1016/S0040-4020(01)82781-2
(1969)Doi:10.1248/cpb.30.1925
(1982)Doi:10.1016/S0022-1139(00)82271-X
(1982)