Journal of Pharmaceutical Sciences p. 619 - 621 (1986)
Update date:2022-09-26
Topics:
Holshouser
Kolb
High yields of potential glycol metabolites of p-synephrine, epinephrine, octopamine, and normacromerine can be obtained from the readily available monosubstituted and disubstituted acetophenones. The general procedure involves alpha-bromination followed by displacement with acetate ion and reduction with lithium aluminum hydride. Yields ranged from 46 to 91%. Furthermore, the procedure minimizes some problems inherent in aromatic glycol synthesis which include dimerization and pinacol-pinacolone rearrangement.
View MoreShandong Jincheng Zhonghua Bio-pharmaceutical Co.,Ltd
Contact:+86-533-5415882
Address:Zichuan Economic Development Zone,Zibo City,Shandong Province,China
Contact:+86-25-85281586
Address:13F,Bld2#,South of Longpan Road
Shanghai ZaiQi Bio-Tech Co., Ltd.,
Contact:+86-21-5482 4098
Address:Bldg. No.7, No.201 MinYi Rd,Songjiang CaoHeJing High-Tech Park Shanghai 201516 P,R,China
website:http://www.lidepharma.com
Contact:+86-25-58409506
Address:11F, Building A1, No.288 North Zhongshan Road, Gulou District, Nanjing,210003, P.R.China.
Contact:0833-5590788/5590338/5590055
Address:Victory in the town of Red Star Village,Mount Emei City,industrial concentration area storage processing logistics parkpark
Doi:10.1002/ejoc.201200063
(2012)Doi:10.1002/chem.201404877
(2015)Doi:10.1021/jo01289a049
(1980)Doi:10.1016/S0040-4020(01)82781-2
(1969)Doi:10.1248/cpb.30.1925
(1982)Doi:10.1016/S0022-1139(00)82271-X
(1982)