Journal of Organic Chemistry p. 5401 - 5408 (1991)
Update date:2022-08-04
Topics:
Haraguchi, Kazuhiro
Tanaka, Hiromichi
Maeda, Hideaki
Itoh, Yoshiharu
Saito, Shigeru
Miyasaka, Tadashi
Introduction of a phenylseleno group to the sugar portion of uracil nucleosides and selenoxide elimination reactions of the resulting selenium-containing derivatives are described.A phenylselenide anion prepared by reducing (PhSe)2 with LiAlH4 was found to be highly reactive.By using this selenide as a nucleophile, ring openings of various types of cyclonucleosides and nucleosides having an anhydro structure in the sugar portion were accomplished.The products, which contain a phenylseleno group in the sugar portion, were oxidized with m-CPBA in CH2Cl2, and their susceptibility to the selenoxide elimination and regiochemistry of the reaction was investigated.
View MoreHunan Zhongqi Pharmaceutical Co., Ltd
website:http://www.hnzqzy.com
Contact:0730-8722288 13807308622
Address:Wanjiafan Road ,Yueyang Economic And Technological Development Zone ,Hunan,PRC
Hangzhou LINGEBA Technology Co., Ltd.
Contact:+0086-571-87389059
Address:Office 1-913,NewYouth Plaza, GongShu Area, HangZhou,ZheJiang,P.R.China
Contact:86+21-56421993
Address:3F,BUILDING 10,NO.2889 JINKE ROAD, SHANGHAI.
Shanghai Send Pharmaceutical Technology Co., Ltd.
website:http://www.shsendpharma.com
Contact:021-58088081, +8613585868794
Address::Room A601, Building 1,NO. 800 Qingdai Road Pudong District Shanghai,China
CGeneTech (Suzhou, China) Co., Ltd.
Contact:+86-512-62956962
Address:Room 101，Bld C11,218 Xinghu Rd.,Suzhou industrial Park
Doi:10.1016/S0022-328X(00)84978-5
(1973)Doi:10.1016/S0008-6215(00)84219-6
(1978)Doi:10.1080/00397919708006059
(1997)Doi:10.1007/BF01141713
(1984)Doi:10.1021/jo01319a052
(1979)Doi:10.1246/bcsj.51.3008
(1978)
