An Excursion into the Synthesis of Potential Angiotensin Converting Enzyme Inhibitors

DOI: 10.1021/jo00142a005

Source and publish data:

Journal of Organic Chemistry p. 4029 - 4032 (1982)

Update date:2022-07-29

Topics:

Authors:

Nitz, Theodore J.

Lindsey, John

Stammer, Charles H.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jo00142a005

An attempt to prepare dehydro analogues of 1 gave the expected tripeptide 2a, but rearrangement of a thiazolone derivative of Δ^Z-Phe made only a thiazolinecarboxylic acid (8) available.The latter was also converted into a tripeptide (11) and both compounds, 2a and 11, showed moderate angiotensin converting enzyme inhibition.

Full text of DOI:10.1021/jo00142a005

Products guided by the article

Product name:N-(trans-2,4-diphenyl-2-thiazolin-5-ylcarbonyl)glycylproline

Cas No:82865-32-5

R&D Labs maybe for 82865-32-5

Neworld Chemical Co., Ltd Shanghai(expird)

Contact:+86-21-62202658

Address:11F, Blvd 2, No. 1969 PuXing Rd, Shanghai
Shantou Baokang Pharmaceutical Co., Ltd.

Contact:+86-754-88873487

Address:5/F B Block Huangshan Bldg Huangshan Rd Shantou
TIC Gums, Inc.

Contact:410-273-7300; 800-221-3953

Address:4609 Richlynn Dr., PO Box 369, Belcamp, MD, 21017-0369, USA
Jinan Jiaquan Chemical Co.,Ltd

Contact:+86-531-62318366

Address:Room 502 of Yidonghuayuan No.601 Huaxin Road Licheng District Jinan China
chengdu firsterchem Pharmaceutical Co., Ltd.

Contact:028-66825849

Address:chengdu

Relevant to this article

New imidazo[2,1-b]thiazole derivatives: Synthesis, in vitro anticancer evaluation, and in silico studies

Doi:10.1016/j.ejmech.2011.08.024
(2011)
Total Synthesis of (+/-)-Pisiferic Acid, Methyl (+/-)-Pisiferate, and (+/-)-Pisiferol

Doi:10.1246/bcsj.55.1599
(1982)
Doi:10.1021/ja00386a029
(1982)
Nonsteroidal Estrogens: Synthesis and Estrogen Receptor Binding Affinity of Derivatives of (3R^*,4S^*)-3,4-Bis(4-hydroxyphenyl)hexane (Hexestrol) and (2R^*,3S^*)-2,3-Bis(4-hydroxyphenyl)pentane (Norhexestrol) Functionalized on the Side Chain

Doi:10.1021/jm00353a006
(1982)
Studies on pyrimidine derivatives. XXVIII. Synthesis of pyridopyrimidine derivatives by cross-coupling of halopyrimidines with olefins and acetylenes

Doi:10.1248/cpb.30.2410
(1982)
CARBOXYLATION OF 1-ACYLINDOLES WITH CARBON MONOXIDE AND PALLADIUM ACETATE IN THE PRESENCE OF SODIUM PEROXYDISULFATE

Doi:10.1246/cl.1982.1151
(1982)

Article Doi