An Excursion into the Synthesis of Potential Angiotensin Converting Enzyme Inhibitors

Article abstract of DOI:10.1021/jo00142a005

An attempt to prepare dehydro analogues of 1 gave the expected tripeptide 2a, but rearrangement of a thiazolone derivative of Δ^Z-Phe made only a thiazolinecarboxylic acid (8) available.The latter was also converted into a tripeptide (11) and both compounds, 2a and 11, showed moderate angiotensin converting enzyme inhibition.