An Excursion into the Synthesis of Potential Angiotensin Converting Enzyme Inhibitors

DOI: 10.1021/jo00142a005

Source and publish data:

Journal of Organic Chemistry p. 4029 - 4032 (1982)

Update date:2022-07-29

Topics:

Authors:

Nitz, Theodore J.

Lindsey, John

Stammer, Charles H.

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Article abstract of DOI:10.1021/jo00142a005

An attempt to prepare dehydro analogues of 1 gave the expected tripeptide 2a, but rearrangement of a thiazolone derivative of Δ^Z-Phe made only a thiazolinecarboxylic acid (8) available.The latter was also converted into a tripeptide (11) and both compounds, 2a and 11, showed moderate angiotensin converting enzyme inhibition.

Full text of DOI:10.1021/jo00142a005

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