A new method of reducing 2-mercapto-substituted 1,3,4-oxadizoles: Synthesis of acylhydrazine derivatives

Article abstract of DOI:10.2174/157017810791514670

A new method has been developed for the synthesis of acylhydrazines 5a-g by the reduction of unsymmetrical 1,3,4-oxadiazoles 4a-g by using sodium borohydride/acetic acid combination. Later on, acylhydrazines 5a-g were converted to their corresponding sulfonamide derivatives 6a-d.