FeCl3-catalyzed conjugate addition of secondary amines, imidazole and pyrazole to methyl-2-acetamidoacrylate. Preparation of β-dialkylamino-α-alanine and β-(N-heteroaryl)-α-alanine derivatives

Article abstract of DOI:10.1016/0040-4020(95)00446-F

β-Dialkylamino-α-alanine and β-(N-heteroaryl)-α-alanine derivatives are obtained by conjugate addition of nitrogen based nucleophiles (cyclic and acyclic secondary amines, imidazole and pirazole) to methyl 2-acetamidoacrylate 1, under iron(III) chloride catalysis.