One step regioselective synthesis of 5-aminoisoxazoles from nitrile oxides and α-cyanoenamines

Article abstract of DOI:10.3390/90700527

The 1,3-dipolar cycloaddition of nitrile oxides to 1-cyanoenamines gives 5-aminoisoxazoles regioselectively. Moderate to good yields could be obtained depending on the method used to generate the nitrile oxides. The intermediate isoxazolines could not be isolated.