New Chiral Stationary Phases with Two Chiral Centers for the Liquid Chromatographic Resolution of Racemic Anti-inflammatory Drugs Related to α-Arylpropionic Acids

Article abstract of DOI:10.1246/cl.1994.1021

New chiral stationary phases (CSPs) with two chiral centers were prepared from (R)- or (S)-α-naphthylethylamine and (S)-naproxen.The (R,S)-CSP prepared from (R)-α-naphthylethylamine and (S)-naproxen was found to be very successful in resolving 3,5-dinitroanilide derivatives of antiinflammatory drugs related to α-arylpropionic acids.