A Facile Synthesis of Polyfunctionally Substituted Pyridines from Ethoxycarbonylmalonaldehyde

DOI: 10.1055/s-1986-31651

Source and publish data:

Synthesis p. 400 - 402 (1986)

Update date:2022-08-03

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Authors:

Torii, Sigeru

Inokuchi, Tsutomu

Kubota, Minoru

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Article abstract of DOI:10.1055/s-1986-31651

A facile access to 2,3-disubstituted-5-ethoxycarbonylpyridines (50-66percent yields), derivatives of biologically and medicinally important nicotinic acid, is explored.The method involves the reaction of ethoxycarbonylmalonaldehyde with tosyl chloride and then with β-amino-α,β-unsaturated esters, ketones, or nitriles in the presence of pyridine.

Full text of DOI:10.1055/s-1986-31651

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