A Facile Synthesis of Polyfunctionally Substituted Pyridines from Ethoxycarbonylmalonaldehyde

Article abstract of DOI:10.1055/s-1986-31651

A facile access to 2,3-disubstituted-5-ethoxycarbonylpyridines (50-66percent yields), derivatives of biologically and medicinally important nicotinic acid, is explored.The method involves the reaction of ethoxycarbonylmalonaldehyde with tosyl chloride and then with β-amino-α,β-unsaturated esters, ketones, or nitriles in the presence of pyridine.