Structure-based optimization of protein tyrosine phosphatase 1B inhibitors: From the active site to the second phosphotyrosine binding site

DOI: 10.1021/jm0702478

Source and publish data:

Journal of Medicinal Chemistry p. 4681 - 4698 (2007)

Update date:2022-09-26

Topics:

Authors:

Wilson, Douglas P.

Wan, Zhao-Kui

Xu, Wei-Xin

Kirincich, Steven J.

Follows, Bruce C.

Joseph-McCarthy, Diane

Foreman, Kenneth

Moretto, Alessandro

Wu, Junjun

Zhu, Min

Binnun, Eva

Zhang, Yan-Ling

Tam, May

Erbe, David V.

Tobin, James

Xu, Xin Xu, Xin

Leung, Louis

Shilling, Adam

Tam, Steve Y.

Mansour, Tarek S.

Lee, Jinbo

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Article abstract of DOI:10.1021/jm0702478

Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of the insulin and leptin receptor pathways and thus an attractive therapeutic target for diabetes and obesity. Starting with a high micromolar lead compound, structure-based optimization of

Full text of DOI:10.1021/jm0702478

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