Journal of Organic Chemistry p. 7715 - 7720 (2005)
Update date:2022-09-26
Topics: Synthesis Inhibitor Kinetic Analysis
Knapp, Spencer
Yang, Chunhua
Pabbaraja, Srihari
Rempel, Brian
Reid, Steven
Withers, Stephen G.
An efficient 10-step preparation from 4-methoxypyridine of (2R,3R,4R)-2-acetamido-3,4-dihydroxy-piperidine ("XylNAc-isofagomine") in optically active form is described. Key steps include an enantioselective reduction with catecholborane/(S)-2-methyl-CBS-o
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Doi:10.1021/op050106k
(2005)Doi:10.1002/chem.200500073
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(2005)
