Base-induced cyclization of 1-benzyloxy-2,2,4,4-tetramethylpentan-3-ones: Intramolecular nucleophilic addition of an anion of a benzyl ether to the carbonyl moiety without the Wittig rearrangement or protophilic decomposition

DOI: 10.1039/a706802f

Source and publish data:

Chemical Communications p. 2395 - 2396 (1997)

Update date:2022-08-03

Topics:

Authors:

Matsumoto, Masakatsu

Watanabe, Nobuko

Ishikawa, Akio

Murakami, Hiroyuki

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Article abstract of DOI:10.1039/a706802f

Alkyl benzyl ethers bearing a carbonyl moiety in the alkyl chain (1) cyclize effectively, without the Wittig rearrangement or protophilic decomposition, to give hydroxytetrahydrofurans (trans-2) on treatment with Bu^tOK in DMSO at room temperatu

Full text of DOI:10.1039/a706802f

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