Inhibition of Renin by Angiotensinogen Peptide Fragmeents Containing the Hydroxy Amino Acid Residue 5-Amino-3-hydroxy-7-methyloctanoic Acid

DOI: 10.1021/jm00364a019

Source and publish data:

Journal of Medicinal Chemistry p. 1457 - 1462 (1983)

Update date:2022-08-05

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Authors:

Johnson, Rodney L.

Verschoor, Karen

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Article abstract of DOI:10.1021/jm00364a019

The 3R,5S and 3S,5S diastereoisomers of the hydroxy amino acid 5-amino-3-hydroxy-7-methyloctanoic acid (AHMOA) were synthesized from L-leucine and then incorporated into various peptide fragments of angiotensinogen to give the following polypeptides: AHMO

Full text of DOI:10.1021/jm00364a019

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