Synthesis and Substituent Effects on Antibacterial Activity, Alkaline Hydrolysis Rates, and Infrared Absorption Frequencies of Some Cephem Analogues Related to Latamoxef (Moxalactam)

DOI: 10.1021/jm00365a006

Source and publish data:

Journal of Medicinal Chemistry p. 1577 - 1582 (1983)

Update date:2022-08-05

Topics: Synthesis IR spectroscopy Spectrophotometry Minimum inhibitory concentration (MIC) Substituent Effects Structure-Activity Relationship (SAR) Alkaline Hydrolysis Cephem Hydrolysis kinetics Chromatography (HPLC/TLC) β-Lactam Ring

Authors:

Narisada, Masayuki

Yoshida, Tadashi

Ohtani, Mitsuaki

Ezumi, Kiyoshi

Takasuka, Mamoru

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Article abstract of DOI:10.1021/jm00365a006

Relationships between intrinsic antibacterial activity and β-lactam reactivity of 7β-<(4-hydroxyphenyl)acetyl>amino- and 7β-<(4-hydroxyphenyl)malonyl>amino derivatives of 1-oxa- and 1-thiacephems, with or without the 7α-methoxy group (1-8), were investiga

Full text of DOI:10.1021/jm00365a006

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