Diphenyl ethers as androgen receptor antagonists for the topical suppression of sebum production

Article abstract of DOI:10.1016/j.bmcl.2009.02.104

A series of diphenyl ethers was prepared and evaluated for androgen receptor antagonist activity in human androgen receptor binding and cellular functional assays. Analogs with potent in vitro activities were evaluated for topical in vivo efficacy in the