Bioorganic and Medicinal Chemistry Letters p. 1908 - 1911 (2007)
Update date:2022-08-02
Topics:
Dodd, Dharmpal S.
Sheriff, Steven
Chang, ChiehYing J.
Stetsko, Dawn K.
Phillips, Linda M.
Zhang, Yingru
Launay, Michele
Potin, Dominique
Vaccaro, Wayne
Poss, Michael A.
McKinnon, Murray
Barrish, Joel C.
Suchard, Suzanne J.
Murali Dhar
A new class of lymphocyte function-associated antigen-1 (LFA-1) antagonists is described. Elaboration of the 2,3-dihydro-1H-pyrrolizin-5(7aH)-one scaffold resulted in the synthesis of potent inhibitors of the LFA-1/ICAM-1 interaction. Along with the in vi
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