Total synthesis of 8,12-iso-iPF3α-VI, an EPA-derived isoprostane: Stereoselective introduction of the fifth asymmetric center

DOI: 10.1021/jo051916x

Source and publish data:

Journal of Organic Chemistry p. 1370 - 1379 (2006)

Update date:2022-08-03

Topics:

Authors:

Jacobo, Sheila H.

Chang, Chih-Tsung

Lee, Gue-Jae

Lawson, John A.

Powell, William S.

Pratico, Domenico

FitzGerald, Garret A.

Rokach, Joshua

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Article abstract of DOI:10.1021/jo051916x

A new and stereoselective approach for the synthesis of all-syn isoprostanes is reported. This method, which is based on acid-catalyzed Diels-Alder reaction, allows the introduction of the side chain with a predetermined stereochemistry of the hydroxy gro

Full text of DOI:10.1021/jo051916x

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